Équipe 2
The Endoplasmic Reticulum (ER) is the first compartment of the secretory pathway in Eukaryotic cells. One of its major roles is to ensure proper secretory protein folding and export to their final destination. In cases where folding is not properly achieved, improperly folded proteins accumulate in the ER and an adaptive response termed the Unfolded Protein Response (UPR) is activated in order to restore ER homeostasis.
The UPR is activated in various physiological and pathophysiological situations. In particular it has been shown to play critical roles in developmental processes as well as in diabetes, neurodegenerative, protein misfolding disease or cancers.
We study the role played by the UPR in cancer progression and development. Our main objectives are to i) characterize UPR signaling networks and ii) artificially modulate them as potential therapeutic strategies.
At present time, three major projects are ongoing in the laboratory:
1) Characterization of IRE1 signaling pathways in cancer: role of the RIDD and structure/function analyses of IRE1 natural mutants
2) PDI signaling networks in primary liver cancers
3) Roles of the AAA+ ATPase VCP in ER stress-induced transcriptional response
The Team is responsible for the management of the Alphascreen Platform.
The lab as we want it to be
The lab, the way it is…
