First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2)
Pontin (RUVBL1, TIP49…) and Reptin (RUVBL2, TIP48…) have recently attracted a lot of attention.
Since the first publications in the late 1990s, the field has been steadily expanding with many publications in high-profile journals, testifying of its good dynamics. Several general reviews also appeared recently and pointed at a number of unsolved issues or discrepancies related to the biochemistry, structural biology or functions of these pleiotropic proteins.
We thus believe that the time is right to gather the community interested in these proteins at the occasion of the first ever workshop in this field. This will be a superb opportunity to discuss informally, try to resolve controversies and establish consensus, share tools etc.
Among the many issues that could be discussed: what is the topology of the Reptin-Pontin complexes, is there a function for monomers, why are there so many different results regarding their ATPase or helicase activity, what are their functions out of the nucleus, what are their common/specific functions, how are they regulated, are they druggable ?
The meeting will take place in the Bordeaux area (France) on October 16-19, 2012, on the site of the European Institute for Chemistry and Biology.
The organizing committee:
Jean Rosenbaum, Bordeaux, France;jean.rosenbaum@inserm.fr
Otmar Huber, Jena, Germany; otmar.huber@mti.uni-jena.de
Ted Hupp, Edinburgh, UK; Ted.Hupp@ed.ac.uk
Contact: secgref@u-bordeaux2.fr
* logo courtesy of J Dessolin, IECB